Fast Five Quiz: Lipids Management: High HDL Cholesterol Levels (Hyperalphalipoproteinemia)

Romesh Khardori, MD, PhD


December 03, 2020

Synthetic progesterone is not associated with HALP, although oral estrogen not opposed by synthetic progesterone can lead to elevated HDL-C levels. Sustained excessive consumption of alcohol is one cause of HALP; when this is identified as the secondary cause, assess the patient for other consequences of this behavior. Other causes of HALP include treatment with statins, niacin (> 1 g/day), the antiseizure medication phenytoin, or fibrates (eg, bezafibrate, clofibrate, fenofibrate, gemfibrozil). A history of high-impact and sustained exercise may also cause HALP. Primary factors include familial syndromes, some of which may be associated with decreased atherogenic risk. 

Learn more about causes of HALP.


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