Fast Five Quiz: Multiple Sclerosis Signs and Symptoms

Christopher Luzzio, MD


January 05, 2021

Figure 1. This color enhanced, T2 weighted, sagittal (from the side) FLAIR MRI of a person with long-standing multiple sclerosis shows multiple hyperintense lesions (yellow) in the periventricular white matter, which is characteristic of demyelinating lesions of MS.

Up to 85% of patients with MS present with episodes of neurologic dysfunction (relapses), which are followed by complete or incomplete recovery. The most common presenting symptom is sensory, followed by visual symptoms.

Optic neuritis, a well-understood clinically isolated syndrome associated with MS, is an inflammatory injury of the optic nerve involving the afferent visual pathway. Optic neuritis marks the first demyelinating event in approximately 20% of patients with MS and eventually develops in approximately 40% of patients over the course of the disease.

Some patients with MS experience a primary progressive course from onset, but the incidence of this form of disease is approximately 10%. Approximately 85% of cases are relapsing-remitting.

There is poor correlation between cognitive dysfunction and physical disability in MS.

Learn more about the presentation of MS.


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