Fast Five Quiz: Multiple Sclerosis Signs and Symptoms

Christopher Luzzio, MD


January 05, 2021

In the past, more than one episode of neurologic disturbance was required for a diagnosis of MS. Now, the 2017 McDonald criteria allow diagnosis after the first clinical episode in conjunction with other paraclinical and MRI data.

A common misconception is that any attack of CNS demyelination indicates acute MS, but this should be one consideration in a broad differential.

An MS attack or exacerbation is marked by a neurologic disturbance documented by either subjective report or objective observation. Definitionally, an episode must last for at least 24 hours.

Learn more about the diagnosis of MS.


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