Fast Five Quiz: Metformin

Mary L. Windle, PharmD


December 22, 2020

Metformin is contraindicated in patients with severe renal dysfunction, metabolic acidosis, and hypersensitivity to the drug. The prescribing information recommends stopping use in patients with vomiting, nausea, and dehydration, owing to the risk for lactic acidosis.

A recent study found that metformin may confer motor function benefit in patients with both Parkinson's disease and diabetes. Metformin has been shown to have a negligible effect on hypothalamic-pituitary-thyroid axis activity in patients with subclinical hyperthyroidism. In addition to use in type 2 diabetes, metformin also has several non–US Food and Drug Administration (FDA)-approved indications, including gestational diabetes, antipsychotic-induced weight gain, and the treatment and prevention of polycystic ovary syndrome.

Read more about prescribing information for metformin.


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