Fast Five Quiz: Early-Stage Breast Cancer

Maurie Markman, MD; Pavani Chalasani, MD, MPH


June 07, 2022

Radiation therapy after breast-conserving surgery is used to eradicate local residual disease, minimizing the possibility of breast cancer recurrence. For women with early-stage breast cancer, treatment with breast-conserving surgery followed by adjuvant radiation therapy is the standard of care, per Gupta and colleagues. Radiation therapy may be combined with other adjuvant or neoadjuvant therapies, such as hormonal therapy and/or chemotherapy, as indicated.

Tumor gene expression assays are a form of personalized medicine used for cancer diagnosis, prognosis, and treatment predictions. Identifying biomarkers may predict the risk for cancer recurrence and response to treatment. For example, in hormone receptor–positive patients, genomic profiling has been widely used to guide treatment with chemotherapy as adjuvant therapy.

The goal of endocrine therapies is to prevent hormone-dependent stimulation of cancer cells. According to the updated guidelines from the American Society of Clinical Oncology (ASCO), adjuvant endocrine therapy should be considered in patients older than 50 years with hormone receptor–positive, node-negative tumors with an Oncotype DX recurrence score < 26, and in those aged 50 years or younger with an Oncotype DX recurrence score < 16.

For additional information, refer to the ASCO treatment guidelines.

Learn more about treatment options for early-stage breast cancer.

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