Fast Five Quiz: Follicular Lymphoma

Emmanuel C. Besa, MD


January 05, 2021

Lymphadenopathy is painless and rubbery. About half of patients will have an enlarged spleen at presentation; some may also have hepatomegaly. Bone marrow involvement at presentation is common. Although it primarily appears in nodes, follicular lymphoma can also make its first appearance at extranodal sites, most prominently the skin and gastrointestinal tract. This may affect prognosis — for example, compared with primary nodal disease, early-stage skin and duodenal disease have a better outcome, whereas muscle, connective tissue, and nervous system cancers result in worse survival.

The sex distribution among people with follicular lymphoma is roughly equal.

Such symptoms as fever, night sweats, and asthenia are seldom evident at presentation; they are likelier to occur with transformation to large diffuse B-cell lymphoma.

Estimates of the total percentage of patients who experience histologic transformation to diffuse large B-cell lymphoma range from 10% to 70%, but as an annual event, it is uncommon, occurring in about 2%-3% per year. This development is associated with poor outcomes.

Learn more about follicular lymphoma.


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