Fast Five Quiz: Follicular Lymphoma Management

Emmanuel C. Besa, MD


January 05, 2021

The stage of follicular lymphoma, an indolent subtype of non-Hodgkin lymphoma, determines the management. Most patients have widespread disease on presentation; for them, cure is not achievable, yet median survival can range from 8 to 15 years. Watchful waiting is appropriate for some patients. For others, excision, radiation, stem cell transplant, and/or single- or multiagent chemotherapy may be indicated.

The Follicular Lymphoma International Prognostic Index (FLIPI) can predict overall and progression-free survival on the basis of age (≤ 60 vs > 60 years), serum lactate dehydrogenase level (normal vs elevated), stage (I or II vs III or IV), hemoglobin level (≥ 120 g/L vs < 120 g/L), and the number of nodal areas (≤ 4 vs > 4). The FLIPI-2 revision substitutes elevated beta-2 microglobulin level and lymph nodes > 6 cm for serum lactate dehydrogenase and number of nodal areas.

However, neither prognostic tool is helpful in predicting response to therapy, nor for patient selection for therapy.

How much do you know about managing follicular lymphoma? Test your knowledge with this quick quiz.


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