Fast Five Quiz: Fibrodysplasia Ossificans Progressiva

Dirk M. Elston, MD


January 14, 2021

Chronic neurologic symptoms are common in patients with FOP, particularly neuropathic pain, and especially in females (15%). Patients also experience other sensory abnormalities.

FOP is a disabling disease that may lead to immobilization, and as mobility begins to devolve, patients may become more prone to respiratory infection or right-sided congestive heart failure.

Hearing loss, usually conductive, is seen in approximately 50% of FOP cases. This symptom may be due to middle-ear ossification, but in other patients hearing impairment is sensorineural, involving the inner ear, cochlea, or the auditory nerve.

Learn more about clinical presentation of FOP.


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