Fast Five Quiz: Type 2 Inflammation in Severe Asthma

Zab Mosenifar, MD

Disclosures

January 20, 2021

Some of the most common causes of type 2 inflammation in asthma are rooted in modifiable problems, such as poor adherence to treatment regimen (intentional or not) or improper inhaler use. Adherence can be assessed objectively through blood prednisone levels or electronic inhaler monitoring.

Asthma symptoms and response to treatment should be assessed every 1-3 months. The Asthma Control Test notes that, ideally, patients with asthma should:

  • Experience symptoms less than twice a week

  • Not wake up at night due to asthma symptoms

  • Need one or fewer courses of prednisone in a year

  • Exhibit normal lung function as measured by spirometry

Although patients who require maintenance OCS may also have underlying type 2 inflammation, it’s important to note that this therapy often suppresses biomarkers of type 2 inflammation (blood eosinophils, sputum eosinophils, and FeNO). Therefore, it’s recommended that assessment be performed before starting therapy or on a very low dose.

Learn more about asthma guidelines.

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