Fast Five Quiz: Waldenström Macroglobulinemia Complications

Emmanuel C. Besa, MD


February 01, 2021

Figure 1. Anemia, conceptual image. Computer artwork of normal red blood cells (red) and anemic red blood cells (clear). The anemic cells are no longer red as they have lost their hemoglobin and therefore their ability to carry iron.

The most common early symptoms of WM are fatigue and weakness characteristic of anemia, present in 80% of patients with symptomatic WM. Normocytic anemia, leukopenia, and thrombocytopenia may also be observed.

About 10% of WM patients have cold agglutinin disease, an acquired hemolytic anemia. Similarly, Raynaud syndrome (associated with both cold agglutinin disease and cryoglobulinemia) can occur in WM.

While progressive reduction in kidney function may occur with WM, acute kidney failure is rare.

Learn more about presentation of WM.


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