Primary amyloidosis of the heart, kidney, liver, lungs, and joints is a rare complication of IgM gammopathies. If a patient presents with symptoms suggestive of the condition (neuropathy, nephrotic syndrome, or cardiac failure), then abdominal fat-pad needle aspiration, along with bone marrow biopsy, is recommended.
Other more common complications of WM include the following:
Visual disturbances secondary to hyperviscosity syndrome
Diarrhea and malabsorption secondary to gastrointestinal (GI) involvement
Renal disease (less common)
Bleeding manifestations secondary to platelet dysfunction and coagulation factor and fibrinogen abnormalities due to interaction with plasma IgM
Raynaud phenomenon secondary to cryoglobulinemia
Increased predisposition to infection due to B-cell dysfunction (disease related) or T-cell dysfunction (therapy related, particularly after nucleoside analogues)
Increased incidence of lymphomas, myelodysplasia, and leukemias
Learn more about complications of WM.
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Cite this: Emmanuel C. Besa. Fast Five Quiz: Waldenström Macroglobulinemia Complications - Medscape - Feb 01, 2021.