The presence of symptomatic or asymptomatic atherosclerotic involvement of LEAD is a critical factor in prognosis. Even patients with more moderate symptoms or asymptomatic disease face a prognostic disadvantage because of cardiovascular or cerebrovascular complications. The prevalence of LEAD is high, particularly in individuals older than 65 years. Patients with LEAD have significantly less chance of receiving appropriate risk factor modification than patients with coronary or cerebrovascular disease.
Although 25% of patients experience symptomatic deterioration, 2%-5% eventually lose the involved leg within 5 years.
The association of hypertension with LEAD is lower than the association of hypertension with coronary artery disease or cerebrovascular disease. Conversely, smoking is three times more likely to cause LEAD than coronary artery disease.
The risk for stroke in male patients with LEAD has been reported to be four to five times higher than in patients without LEAD.
Learn more about noncoronary atherosclerosis.
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Cite this: Yasmine S. Ali. Fast Five Quiz: Noncoronary Atherosclerosis Signs and Symptoms - Medscape - Mar 01, 2021.