Fast Five Quiz: Primary Hyperoxaluria Type 1

Bradley Schwartz, DO

Disclosures

February 25, 2021

In PH1, when glomerular filtration rate drops to 30-45 mL/min/1.73 m2 of body surface area, the kidney is no longer able to proficiently excrete the oxalate load it receives. As a result, plasma oxalate increases and soon exceeds saturation, resulting in systemic oxalosis. Systemic oxalosis leads to oxalate deposition in the bone, kidneys, skin, retina, myocardium, vessel walls, and central nervous system.

As kidney function declines, the systemic storage of plasma oxalate increases. Improper management prior to kidney transplantation may precipitate oxalate storage in the renal graft, which can lead to premature allograft dysfunction or loss.

Learn more about the pathophysiology of PH1.

Comments

3090D553-9492-4563-8681-AD288FA52ACE
Comments on Medscape are moderated and should be professional in tone and on topic. You must declare any conflicts of interest related to your comments and responses. Please see our Commenting Guide for further information. We reserve the right to remove posts at our sole discretion.
Post as:

processing....