Fast Five Quiz: Primary Hyperoxaluria Type 1

Bradley Schwartz, DO

Disclosures

February 25, 2021

PH1 can result in various systemic manifestations due to the deposition of oxalate. Systemic manifestation may include bone pain and pathologic fractures, as well as joint involvement (synovitis) and chondrocalcinosis.

Other reported systemic manifestations include vascular manifestations (nonhealing ulcers, gangrene resulting from ischemia of blood vessels, and refractory hypotension); heart manifestations (conduction defects, heart blocks, and cardiomyopathy); nervous system manifestations (peripheral neuropathy, retinopathy, and cerebral infarcts); and hematologic manifestations (anemia due to oxalate deposition in the bone marrow that is unresponsive to erythropoietin-stimulating agents).

Learn more details about the clinical manifestations of PH1.

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