Fast Five Quiz: Primary Hyperoxaluria Type 1 Screening and Diagnosis

Bradley Schwartz, DO


December 15, 2022

Figure 1. Stage 5 kidney disease.

Kidney stones are the most common clinical manifestation that may lead to a diagnosis of PH1. Guidelines for the screening and diagnosis of PH1 suggest that the diagnosis of PH should be suspected in children and infants with a first kidney stone and in adults with recurrent kidney stones.

Other clinical manifestations that should raise clinical suspicion for PH1 include:

  • Calcium oxalate monohydrate kidney stones

  • Nephrocalcinosis and decreased GFR

  • Progressive decline in kidney function of unknown cause

  • Failure to thrive in infancy

Learn more about screening for and diagnosing PH1.


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