Fast Five Quiz: Primary Hyperoxaluria Type 1 Screening and Diagnosis

Bradley Schwartz, DO


December 15, 2022

A clinical diagnosis of PH1 relies in part on metabolic screening. Urinary oxalate excretion exceeding 40-45 mg (< 0.50 mmol)/1.73 m2/24 h define hyperoxaluria. In individuals with reduced kidney function, the kidneys are unable to excrete oxalate efficiently, so urinary oxalate measurements may be falsely low. However, plasma oxalate levels begin to rise. Plasma oxalate levels of > 50 μmol/L are suggestive of PH1. In addition, higher plasma oxalate levels may be a risk factor for end-stage kidney disease (ESKD).

Learn more about the workup for PH1.


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