Fast Five Quiz: Primary Hyperoxaluria Type 1 Management

Bradley Schwartz, DO


March 04, 2022

Most experts suggest that dual liver-kidney transplantation be considered for patients with estimated glomerular filtration rate < 30 mL/min/1.73 m2 . At this stage of kidney dysfunction, oxalate retention increases, making the progression to end-stage disease nearly inevitable.

Isolated kidney transplantation is not curative in PH1. This is because the biochemical defect associated with the disease occurs in the liver and the overproduction of oxalate and ensuing deposition in tissues continues unabated even after kidney transplant.

For most patients, sequential liver-kidney transplant is recommended and should be performed as early as possible to achieve a cure. In some patients, early liver transplant before the development of kidney injury may be possible and may preserve the native kidneys.

Learn more details about the management of PH1.


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