Fast Five Quiz: Noncoronary Atherosclerosis

Yasmine S. Ali, MD


March 01, 2021

Figure 1. Photograph of atherosclerosis, showing the surface of a calcified blood vessel.

The response to injury theory is the most universally accepted explanation for atherogenesis. Endothelial injury causes vascular inflammation, which prompts a fibroproliferative response. Among possible causes of endothelial injury are oxidized low-density lipoprotein cholesterol; infectious agents; toxins, including the by-products of cigarette smoking; hyperglycemia; and hyperhomocysteinemia.

Less relevant theories regarding atherogenesis include the hemodynamic theory, the fibrin incrustation theory, the nonspecific mesenchymal hypothesis, and the lipid theory.

Learn more about the etiology of atherosclerosis.


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