Fast Five Quiz: Alzheimer's Disease Workup

Jasvinder P. Chawla, MD, MBA; Shaheen E. Lakhan, MD, PhD, MS, MEd


September 08, 2023

According to guidelines from the American College of Medical Genetics and the National Society of Genetic Counselors, testing for the APP and PSEN genes associated with early-onset autosomal dominant Alzheimer's disease should be offered in these clinical scenarios:

  • In symptomatic patients with early-onset Alzheimer's disease who have either a family history of dementia or an unknown family history (eg, because of adoption)

  • In patients with a family history of autosomal dominant dementia including one or more cases of early-onset Alzheimer's disease

  • In relatives of patients with a mutation consistent with early-onset Alzheimer's disease (PS-1, PS-2, and APP)

Learn more about genetic testing in Alzheimer's disease.

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