Fast Five Quiz: Severe Pediatric Atopic Dermatitis

William D. James, MD


March 15, 2021

Chronic lesions show increased eosinophil infiltration in the skin of patients with atopic dermatitis compared with patients without atopic dermatitis. Increased levels of IL-13 in acute atopic dermatitis skin lesions may directly induce IL-5 expression and eosinophil infiltration, thereby facilitating the transition from acute lesions into chronic lesions.

Levels of type 2 cytokine IL-5 and type 1 cytokines IL-12 and interferon (IFN)-gamma are found to be elevated in chronic atopic dermatitis skin lesions, whereas levels of type 2 cytokines IL-4 and IL-13 are elevated in acute atopic dermatitis lesions.

Skin barrier molecules such as ceramide lipids in stratum corneum and structural protein filaggrin show significantly decreased levels in the skin of patients with atopic dermatitis compared with the skin of patients without atopic dermatitis.

A general increase in exposure to nonpathogenic microbes with unpasteurized farm milk, early day care, endotoxin, and animal exposure is found to have a protective effect and thus decreased risk for pediatric atopic dermatitis.

Learn more about the pathophysiology of pediatric atopic dermatitis.

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