Fast Five Quiz: Parkinson's Disease Nonmotor Symptoms

Jasvinder P. Chawla, MD, MBA


February 25, 2021

Depression is one of the most common neuropsychiatric manifestations in patients with Parkinson's disease and can significantly affect patients' health status. Studies have shown that depression has more than double the impact on health status vs motor symptoms among patients with Parkinson's disease.

Diagnosing depression in Parkinson's disease may be complicated by overlap with other symptoms of Parkinson's disease and clinical features of depression (eg, amotivation, bradykinesia, fatigue, and sleep disturbances). Formal questioning with systematic questionnaires can be diagnostically useful; a number of validated tools are available.

Patients with Parkinson's disease are more likely to be diagnosed with minor depression or dysthymia vs a major depressive disorder. Depressed patients with Parkinson's disease typically have higher rates of anxiety and are less likely to report feelings of guilt or failure than are depressed patients without Parkinson's disease.

Learn more details on the impact of nonmotor symptoms in patients with Parkinson's disease.


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