Fast Five Quiz: Tardive Dyskinesia Management

Christoph U. Correll, MD


June 28, 2023

The American Academy of Neurology guidelines, which were published in 2013 and reaffirmed in 2019, state that Ginkgo biloba may improve TD (Level B) and can be considered for treatment of TD. In addition, positive results with adjunctive Ginkgo biloba for reducing TD symptoms were reported in a meta-analysis of three randomized, placebo-controlled clinical trials; however, more robust data are needed and no regulatory approval exists for this approach. Furthermore, multiple trials have suggested that vitamin E, vitamin B6, and amantadine may be effective for the treatment of TD, though a large-scale randomized controlled trial failed to show a significant effect of vitamin E on TD compared with placebo.

Studies of nonbenzodiazepine muscle relaxants in patients with TD showed no significant improvement in TD compared with placebo. Additionally, patients receiving GABAergic medications were more likely to show deterioration in mental status, fail to complete the study, and experience ataxia or sedation.

The traditional herbal medicines yi-gan san and kamishoyosan were tested in prospective observational open-label studies in patients with schizophrenia. Although some studies have shown possible efficacy, the quality of evidence has been low.

Learn more about recommended treatments for TD.


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