Fast Five Quiz: Tardive Dyskinesia Management

Christoph U. Correll, MD


February 22, 2021

American Academy of Neurology (AAN) guidelines—which were published in 2013 and reaffirmed in 2019—state that benzodiazepine, clonazepam, as well as Ginkgo biloba may improve TD (Level B) and can be considered for treatment. However, clonazepam should not be used for more than 3 months.

The AAN guidelines report that pallidal deep brain stimulation possibly improves TD and might be considered as a last resort treatment for intractable TD (Level C).

The traditional Chinese herbal medicines yi-gan san and kamishoyosan were tested in prospective observational open-label studies in small samples of patients with schizophrenia for 12 and 16 weeks, respectively. Both led to a significant improvement of TD symptoms. However, there is insufficient evidence to support or refute TD treatment by Chinese herbal medicines (Level U).

Learn more about recommended treatments for TD.


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