Fast Five Quiz: Tardive Dyskinesia Risk Factors

Christoph U. Correll, MD; James Robert Brasic, MD, MPH


March 17, 2023

The risk for TD may be reduced by using the lowest effective dose of an antipsychotic for the shortest period. When TD is diagnosed, reduce the dose or discontinue the causative agent if possible. The risk for TD must be weighed against the risk of exacerbating psychosis. It should be noted that TD may worsen initially after antipsychotics are discontinued, which can be mitigated by a slow taper and discontinuation period.

Recent data about antipsychotic-induced TD in patients with schizophrenia underscore the superiority of newer-generation antipsychotics over first-generation antipsychotics in regard to prevalence and incidence rates, though even newer-generation agents carry some risk of developing TD.

Learn more about the workup of TD.


Comments on Medscape are moderated and should be professional in tone and on topic. You must declare any conflicts of interest related to your comments and responses. Please see our Commenting Guide for further information. We reserve the right to remove posts at our sole discretion.