The risk for TD may be reduced by using the lowest effective dose of an antipsychotic for the shortest period. When TD is diagnosed, reduce the dose or discontinue the causative agent if possible. The risk for TD must be weighed against the risk of exacerbating psychosis. It should be noted that TD may worsen initially after antipsychotics are discontinued, which can be mitigated by a slow taper and discontinuation period.
Recent data about antipsychotic-induced TD in patients with schizophrenia underscore the superiority of newer-generation antipsychotics over first-generation antipsychotics in regard to prevalence and incidence rates, though even newer-generation agents carry some risk of developing TD.
Learn more about the workup of TD.
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Cite this: Christoph U. Correll, James Robert Brasic. Fast Five Quiz: Tardive Dyskinesia Risk Factors - Medscape - Mar 17, 2023.