In general, the risk of developing TD is considerably higher among older patients than younger patients, although all patients taking antipsychotics, especially dopamine antagonists, face some risk of developing TD. While risk for TD increases with higher dose, older patients are susceptible to developing TD even after exposure to low doses of second-generation antipsychotics.
The risk for TD is even higher with first-generation antipsychotics. A meta-analysis of 57 head-to-head randomized controlled trials concluded that TD risk and annualized rates were lower with the use of second-generation agents vs first-generation agents. The analysis reported an annualized incidence of 6.5% and 2.6% across first- and second-generation antipsychotic arms, respectively.
Learn more about the etiology of TD.
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Cite this: Christoph U. Correll, James Robert Brasic. Fast Five Quiz: Tardive Dyskinesia Risk Factors - Medscape - Mar 17, 2023.