Fast Five Quiz: Scleroderma Systemic Sclerosis ILD Presentation and Diagnosis

Zab Mosenifar, MD


January 28, 2022

Systemic sclerosis-associated interstitial lung disease (SSc-ILD) is an autoreactive immune connective tissue disorder (CTD) characterized by inflammation, immune dysregulation, microvascular damage, and progressive fibrosis of the skin and internal organs. Fibrosing ILD is a very common manifestation of SSc, thought to be caused by repetitive epithelial injury, activation of the innate and adaptive immune mechanisms, and fibroblast recruitment and activation leading to extracellular matrix accumulation and fibrosis. Diagnosis of SSc-ILD is based on finding ILD on high-resolution CT (HRCT) of the chest in a patient with known SSc, along with normal or abnormal pulmonary function tests (PFTs).

Can you differentiate SSc-ILD from other subtypes? Test your knowledge with this quick quiz.


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