Fast Five Quiz: Scleroderma Systemic Sclerosis ILD Presentation and Diagnosis

Zab Mosenifar, MD


January 28, 2022

Figure 1. HRCT scan of the chest of a 58-year-old man shows peribronchial interstitial changes/reticular opacities and ground glass changes with subpleural sparing. The predominant finding is ground glass opacity. Findings represent nonspecific interstitial pneumonia (NSIP).

The risk of developing ILD is highest early in the course of SSc. Risk factors for the development or progression of ILD in patients with SSc include the presence of diffuse cutaneous systemic sclerosis (dcSSc), African American ethnicity, male sex, and older age at disease onset. Additionally, higher Rodman skin score, high serum creatinine and serum creatine phosphokinase levels, hypothyroidism, and cardiac involvement have been associated with increased risk for development of ILD.

Learn more about the pathophysiology of CTD-ILD.


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