The majority of SSc-ILD cases show a fibrotic nonspecific interstitial pneumonia pattern while a minority (10%-15%) shows a usual interstitial pneumonia pattern. The mortality rates between these two disease patterns do not seem to differ significantly in SSc-ILD. The most common histopathologic finding is nonspecific interstitial pneumonia with peripheral, bibasilar distribution of ground glass opacities. A pattern of usual interstitial pneumonia, characterized by honeycomb cysts and traction bronchiectasis, may also be seen in up to a third of patients with SSc-ILD.
In sarcoidosis, air trapping is a common feature that can be supported with imaging studies and correlates with evidence of small airways disease on PFT.
Learn more about the workup for CTD-ILD.
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Cite this: Zab Mosenifar. Fast Five Quiz: Scleroderma Systemic Sclerosis ILD Presentation and Diagnosis - Medscape - Jan 28, 2022.