Fast Five Quiz: Scleroderma Systemic Sclerosis ILD Presentation and Diagnosis

Zab Mosenifar, MD


March 28, 2023

Anti-topoisomerase (Scl-70) antibodies are highly specific for SSc and have been associated with diffuse skin involvement and interstitial lung fibrosis. Patients with SSc and anti-topoisomerase (Scl-70) antibodies, may be at greater risk of developing ILD and disease progression. In contrast, patients with SSc and anti-centromere antibodies rarely develop SSc-ILD.

Other risk factors for progression in SSc-ILD include presence of diffuse disease, extent of parenchymal disease on HRCT of > 20% and FVC of < 70%.

Learn more about CTD-ILD.


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