The symptoms of EPI generally appear late in the disease course. Because the exocrine pancreas has a large reserve capacity for enzyme secretion, fat digestion is not clearly impaired until approximately 90% of the exocrine function of the pancreas is lost, or when lipase output decreases to below 10% of the normal level. Although this measurement is the current standard for determining fat malabsorption, it is important to consider that EPI can represent a graded response rather than a precise cut-off in pancreatic function. Particularly in view of the condition's indistinct presentation, patients may benefit from early testing.
Learn more about the workup of EPI.
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Cite this: Romesh Khardori. Fast Five Quiz: Exocrine Pancreatic Insufficiency Signs and Symptoms - Medscape - Mar 08, 2021.