Fast Five Quiz: Exocrine Pancreatic Insufficiency Signs and Symptoms

Romesh Khardori, MD, PhD


March 08, 2021

While the leading cause of EPI in adults is chronic pancreatitis, the leading cause of the condition in children is CF. In these cases, a therapeutic strategy that corrects nutritional deficiencies is associated with improved pulmonary function and increased survival. To date, the management of other conditions which lead to EPI in children requires further study, and inferences from CF literature are often necessary in making clinical decisions for young patients. The severity of EPI depends on the specific genotypic mutation, but 85% of patients with CF will also develop EPI, and in vast majority of these patients, the diseases co-occur at birth.

Among nonpancreatic causes of EPI are celiac disease, Crohn's disease, autoimmune pancreatitis, Zollinger-Ellison syndrome, and gastrointestinal and pancreatic surgical procedures.

Learn more about the etiology of EPI.


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