Fast Five Quiz: Myelodysplastic Syndrome Pathology

Emmanuel C. Besa, MD


May 12, 2021

The National Comprehensive Cancer Network (NCCN) utilizes the World Health Organization (WHO) classification system for diagnosis and distinguishes subtypes on the basis of blood and bone marrow findings; the criteria for MDS-RS are:

  • Blood: anemia, no blasts;

  • Bone marrow: ≥ 15% of erythroid precursors with ring sideroblasts or ≥ 5% ring sideroblasts if SF3B1 mutation is present

Patients with less than 5% bone marrow blasts who have 1% blasts in the peripheral blood documented on at least two separate occasions would be considered to have MDS-U.

Learn more about MDS guidelines.


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