Fast Five Quiz: Myelodysplastic Syndrome Pathology

Emmanuel C. Besa, MD


May 12, 2021

MDS-MLD is a type of MDS with one or more cytopenias and dysplastic changes in two or more of the myeloid lineages (erythroid, granulocytic, or megakaryocytic). It is often diagnosed in patients who have a previous diagnosis of lower-grade forms of MDS such as MDS-SLD, MDS-MLD, or MDS-RS. In this context, such a change in diagnosis indicates disease progression.

Progression to AML is less common in patients with MDS with isolated del(5q) than in other forms of MDS.

Close to 25% of patients with idiopathic cytopenia of undetermined significance may ultimately develop MDS or AML.

Secondary MDS and therapy-related MDS both have higher frequency of complex and monosomy karyotypes and higher rates of AML transformation compared to de novo MDS.

Learn more about prognosis in MDS.


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