Pain in the abdomen, flank, or back is almost universally present in patients with ADPKD and is the most common initial sign. Any of the following can be responsible for the pain:
Enlargement of one or more cysts
Bleeding, which may be confined inside the cyst or can lead to gross hematuria with passage of clots or a perinephric hematoma
Urinary tract infection (eg, acute pyelonephritis, infected cysts, perinephric abscess)
Nephrolithiasis and renal colic
In rare cases, a coincidental hypernephroma
Symptoms related to renal failure (eg, pallor, uremic fetor, dry skin, edema) are unusual upon presentation.
Patients with early-stage ADPKD may also report fatigue, breathlessness, weakness, and malaise.
Learn more about the presentation of ADPKD.
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Cite this: Neera K. Dahl. Fast Five Quiz: Autosomal Dominant Polycystic Kidney Disease Presentation and Diagnosis - Medscape - Jun 29, 2021.