Most patients who give a history of penicillin allergy are not truly allergic to beta-lactam antibiotics. After negative allergy testing, amoxicillin can safely be given in H pylori eradication regimens.
A combination of sequential and concomitant therapy (hybrid therapy) has been shown to result in high eradication rates in some populations.
Additional treatments for H pylori are under investigation. One such agent is vonoprazan (VPZ), a potent new acid-inhibitory drug. In a systematic review with meta-analysis, VPZ-based triple therapy was shown to have superior efficacy for second-line H pylori eradication compared with PPI-based triple therapy; this may be due to VPZ's strong and homogeneous acid suppression effect. High-dose dual therapy using a combination of amoxicillin and a PPI for 14 days is another promising approach that has shown good success rates and tolerability in clinical trials.
Learn more about H pylori treatment regimens.
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Cite this: B.S. Anand, Steven F. Moss. Fast Five Quiz: Helicobacter pylori - Medscape - Jan 20, 2022.