Myasthenia gravis (MG) is a rare autoimmune neuromuscular disorder in which antibodies form against postsynaptic nicotinic acetylcholine receptors (AChRs) located at the motor endplate of the neuromuscular junction (NMJ). With a worldwide prevalence of 12.4 people per 100,000 population, MG is one of the most common and well-understood neuromuscular diseases. Other antigenic targets of the NMJ, muscle-specific receptor tyrosine kinase (MuSK) antibody and low-density lipoprotein receptor-related protein 4 antibody, have also been implicated in 5%-8% of all patients with MG. The detection of AChR, via antibody test, in patients with typical clinical symptoms is a key diagnostic marker of MG and helps define the disease subtypes.
How much do you know about the signs and symptoms of MG? Test your knowledge with this quick quiz.
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Cite this: Richard Nowak, Nicholas J. Silvestri. Fast Five Quiz: Myasthenia Gravis Signs and Symptoms - Medscape - Sep 27, 2023.