Fast Five Quiz: Breast Cancer Treatment

Pavani Chalasani, MD, MPH


July 12, 2021

Patients in whom definitive surgery may be delayed would be appropriate candidates for preoperative systemic therapy. Other candidates would be:

Patients with inoperable breast cancer:

  • Inflammatory breast cancer

  • Bulky or matted cN2 axillary nodes

  • cN3 nodal disease

  • cT4 tumors

In patients with operable breast cancer, preoperative systemic therapy is preferred for:

  • HER2-positive disease and triple-negative breast cancer, if cT ≥ 2 or cN ≥ 1

  • Large primary tumor relative to breast size in a patient who desires breast conservation

  • cN+ disease likely to become cN0 with preoperative systemic therapy

Learn more about the treatment of breast cancer.


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