Fast Five Quiz: Pediatric Atopic Dermatitis

Dirk M. Elston, MD


June 07, 2021

Figure 1. A baby with atopic dermatitis.

The risk factors that are consistently associated with the development of AD are loss of function mutations in the FLG gene and a family history of atopy. Although markers for prognosis in AD are inconsistent, FLG gene null mutations tend to predict a more severe and protracted disease course.

Although breastfeeding during the first 4 months of life may reduce the incidence and severity of childhood atopic disease, the reduction is modest and is seen only in those at high risk.

A dog living in the home at the time of birth has been associated with a 50% decrease in the incidence of AD at age 3, whereas cat sensitization has been associated with a significantly increased risk.

There does not seem to be an association between vaginal or cesarean birth and development of AD.

Learn more about the etiology of AD.


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