Fast Five Quiz: Commonly Misdiagnosed Conditions

B.S. Anand, MD; Michael Stuart Bronze, MD; Herbert S. Diamond, MD; Helmi L. Lutsep, MD

Disclosures

June 02, 2021

In September 2019, the EULAR and the ACR published new criteria for the classification of SLE (Table). The EULAR/ACR criteria have sensitivity of 96.1% and specificity of 93.4%, compared with 82.8% sensitivity and 93.4% specificity of the 1997 ACR criteria, and 96.7% sensitivity and 83.7% specificity of the 2012 Systemic Lupus International Collaborating Clinics (SLICC) classification criteria.

Table. EULAR/ACR Clinical Domains and Criteria for SLE

Domain

Criteria

Points

Constitutional

Fever

2

Hematologic

Leukopenia

Thrombocytopenia

Autoimmune hemolysis

3

4

4

Neuropsychiatric

Delirium

Psychosis

Seizure

2

3

5

Mucocutaneous

Nonscarring alopecia

Oral ulcers

Subacute cutaneous or discoid lupus

Acute cutaneous lupus

2

2

4

6

Serosal

Pleural or pericardial effusion

Acute pericarditis

5

6

Musculoskeletal

Joint involvement

6

Renal

Proteinuria > 0.5 g/24 h

Renal biopsy class II or V lupus nephritis

Renal biopsy class III or IV lupus nephritis

4

8

10

ACR = American College of Rheumatology; EULAR = European League Against Rheumatism; SLE = systemic lupus erythematosus

Read more clinical information about SLE.

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