In September 2019, the EULAR and the ACR published new criteria for the classification of SLE (Table). The EULAR/ACR criteria have sensitivity of 96.1% and specificity of 93.4%, compared with 82.8% sensitivity and 93.4% specificity of the 1997 ACR criteria, and 96.7% sensitivity and 83.7% specificity of the 2012 Systemic Lupus International Collaborating Clinics (SLICC) classification criteria.
Table. EULAR/ACR Clinical Domains and Criteria for SLE
Domain |
Criteria |
Points |
---|---|---|
Constitutional |
Fever |
2 |
Hematologic |
Leukopenia Thrombocytopenia Autoimmune hemolysis |
3 4 4 |
Neuropsychiatric |
Delirium Psychosis Seizure |
2 3 5 |
Mucocutaneous |
Nonscarring alopecia Oral ulcers Subacute cutaneous or discoid lupus Acute cutaneous lupus |
2 2 4 6 |
Serosal |
Pleural or pericardial effusion Acute pericarditis |
5 6 |
Musculoskeletal |
Joint involvement |
6 |
Renal |
Proteinuria > 0.5 g/24 h Renal biopsy class II or V lupus nephritis Renal biopsy class III or IV lupus nephritis |
4 8 10 |
ACR = American College of Rheumatology; EULAR = European League Against Rheumatism; SLE = systemic lupus erythematosus |
Read more clinical information about SLE.
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Cite this: B.S. Anand, Michael Stuart Bronze, Herbert S. Diamond, et. al. Fast Five Quiz: Commonly Misdiagnosed Conditions - Medscape - Jun 02, 2021.