Fast Five Quiz: Serotonin Syndrome

Richard H. Sinert, DO


June 04, 2021

Serotonin syndrome typically manifests within 24 hours of exposure to the offending agent. Early manifestations and symptoms of mild serotonin syndrome include the following:

  • Tachycardia

  • Diaphoresis

  • Dilated pupils

  • Myoclonus

  • Increased deep tendon reflexes

  • Restlessness

  • Anxiety

  • Gait abnormalities

  • Difficulty concentrating

  • Sleep disturbances

  • Shivering

  • Muscle twitching

Late manifestations and symptoms of moderate to severe serotonin syndrome include the following:

  • Hyperactive bowel sounds

  • Diarrhea

  • Hypertension

  • Severe hyperthermia

  • Muscle rigidity

  • Disseminated intravascular coagulation

  • Multiple organ failure

  • Shock

Read more about the presentation of serotonin syndrome.


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