Fast Five Quiz: Obstructive Hypertrophic Cardiomyopathy Management

Jamshid Shirani, MD


July 30, 2021

Hypertrophic cardiomyopathy (HCM) is a genetic disease of the heart characterized by left ventricular hypertrophy in the absence of alternative cardiac, systemic, or metabolic diseases capable of causing such hypertrophy. HCM is predominantly caused by mutations in genes encoding for cardiac sarcomere proteins and has an autosomal dominant mode of inheritance. Once the diagnosis is made, management largely depends on the disease phenotype (i.e., obstructive or nonobstructive). More than two thirds of patients with HCM will have resting or provoked (Valsalva maneuver, standing, postexercise) left ventricular outflow tract obstruction or, less commonly, midcavitary obstruction. Other factors that influence the choices of treatment are mitral regurgitation, diastolic dysfunction, myocardial ischemia, arrhythmias, and autonomic dysfunction.

How much do you know about managing patients with obstructive HCM? Test your knowledge with this quick quiz.


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