Fast Five Quiz: Autosomal Dominant Polycystic Kidney Disease (ADPKD)

Neera K. Dahl, MD, PhD


August 06, 2021

Hypertension is one of the most common early manifestations of ADPKD in patients of all ages. The clinical course of hypertension in patients with ADPKD is different from that seen in hypertension associated with chronic glomerulonephritis or tubulointerstitial nephropathies. In ADPKD, hypertension typically is more severe early in the disease course and becomes less problematic as the renal insufficiency progresses. A rise in diastolic pressure is the norm in patients with ADPKD.

Patients with ADPKD are often asymptomatic. Some patients may present early with symptoms such as abdominal or flank pain, macroscopic hematuria, or urinary tract infections. Symptoms related to renal failure, such as pallor, uremic fetor, dry skin, and edema, are rare upon presentation.

Learn more about the clinical presentation of ADPKD.


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