Fast Five Quiz: Precision Medicine in Cancer

Winston W. Tan, MD; Evelyn S. Marienberg, MD

Disclosures

January 06, 2023

Some genetic mutations can significantly alter the choice of treatment or signal that a cancer is more likely to become resistant to a treatment. In colorectal cancers, mutations in the KRAS genes may signal that a patient will not respond to certain drugs targeting the EGFR pathway such as cetuximab or panitumumab.

SRSF2 alterations have not been detected in colon cancer. IDH2 and SF3B1 mutations have been identified in colon cancer at low frequencies; they have not been associated with resistance to drugs targeting the EGFR pathway to date.

Learn more about targeting KRAS.

Comments

3090D553-9492-4563-8681-AD288FA52ACE
Comments on Medscape are moderated and should be professional in tone and on topic. You must declare any conflicts of interest related to your comments and responses. Please see our Commenting Guide for further information. We reserve the right to remove posts at our sole discretion.

processing....