Fast Five Quiz: Acetaminophen

Mary L. Windle, PharmD

Disclosures

July 22, 2021

The maximum recommended daily dose of acetaminophen is 75 mg/kg for children and 4 g for adults. The minimum hepatotoxic dose as a single acute ingestion is 150 mg/kg for a child and 7.5-10 g for an adult. For use to treat pain and fever, these doses are indicated:

  • Regular-strength immediate-release acetaminophen: 325-650 mg orally every 4 hours as needed

  • Extra-strength immediate-release acetaminophen: 1000 mg orally every 6-8 hours as needed

  • Extended-release acetaminophen: 2 capsules (1300 mg) orally every 8 hours as needed

Many nonprescription products contain acetaminophen for treatment of migraine or sinus headaches, cough and cold, or allergies. When calculating the maximum daily dose, consider all sources of acetaminophen, including over-the-counter, as well as routes of administration to avoid exceeding the maximum recommended daily dose. A lower maximum daily dose of 3 g/day is recommended if used for longer durations (ie, 1 week or longer) or if certain conditions exist (eg, alcohol abuse, malnutrition, low body weight, advanced age). A maximum daily dose of 2 g/day is recommended for those with advanced liver disease.

Review more on acetaminophen dosing.

Comments

3090D553-9492-4563-8681-AD288FA52ACE
Comments on Medscape are moderated and should be professional in tone and on topic. You must declare any conflicts of interest related to your comments and responses. Please see our Commenting Guide for further information. We reserve the right to remove posts at our sole discretion.

processing....