Nausea and/or vomiting are among the most commonly reported adverse effects associated with acetaminophen use. Abdominal pain, diarrhea, constipation, dyspepsia, and enlarged abdomen are also somewhat frequently noted. Serious skin reactions (eg, acute generalized exanthematous pustulosis, Stevens-Johnson syndrome, toxic epidermal necrolysis) are rare, although rash and pruritus are more commonly reported. Pemphigoid reaction, pustular rash, and Lyell syndrome are extremely rare adverse effects. Although anemia and postoperative hemorrhage have been somewhat commonly reported, other hematologic adverse effects are very rarely associated with acetaminophen use, including thrombocytopenia, leukopenia, and neutropenia. Insomnia has been associated with acetaminophen use.
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Cite this: Mary L. Windle. Fast Five Quiz: Acetaminophen - Medscape - Jul 22, 2021.