Fast Five Quiz: Acetaminophen

Mary L. Windle, PharmD


July 22, 2021

Nausea and/or vomiting are among the most commonly reported adverse effects associated with acetaminophen use. Abdominal pain, diarrhea, constipation, dyspepsia, and enlarged abdomen are also somewhat frequently noted. Serious skin reactions (eg, acute generalized exanthematous pustulosis, Stevens-Johnson syndrome, toxic epidermal necrolysis) are rare, although rash and pruritus are more commonly reported. Pemphigoid reaction, pustular rash, and Lyell syndrome are extremely rare adverse effects. Although anemia and postoperative hemorrhage have been somewhat commonly reported, other hematologic adverse effects are very rarely associated with acetaminophen use, including thrombocytopenia, leukopenia, and neutropenia. Insomnia has been associated with acetaminophen use.

Review adverse effects associated with acetaminophen use.


Comments on Medscape are moderated and should be professional in tone and on topic. You must declare any conflicts of interest related to your comments and responses. Please see our Commenting Guide for further information. We reserve the right to remove posts at our sole discretion.