Fast Five Quiz: Treatment-Resistant Depression

Ravinder N. Bhalla, MD


August 19, 2021

When there is no response to first-line treatment with an antidepressant, switching medications is recommended. The addition of a second antidepressant is only recommended in the first line in cases of partial response after 4-6 weeks of therapy.

In cases of partial response or nonresponse to second-line antidepressant treatment, optimizing the dose of the initial antidepressant is recommended with a high priority level. Slightly higher remission rates may be obtained with between-class medication switches vs within-class switches.

Learn more about pharmacotherapy for TRD.


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