Fast Five Quiz: Treatment-Resistant Depression

Ravinder N. Bhalla, MD

August 19, 2021

When there is no response to first-line treatment with an antidepressant, switching medications is recommended. The addition of a second antidepressant is only recommended in the first line in cases of partial response after 4-6 weeks of therapy.

In cases of partial response or nonresponse to second-line antidepressant treatment, optimizing the dose of the initial antidepressant is recommended with a high priority level. Slightly higher remission rates may be obtained with between-class medication switches vs within-class switches.

Learn more about pharmacotherapy for TRD.

Editor's Recommendations

1 2 3 4 5 6

Next Section

Any views expressed above are the author's own and do not necessarily reflect the views of WebMD or Medscape.

Cite this: Ravinder N. Bhalla. Fast Five Quiz: Treatment-Resistant Depression - Medscape - Aug 19, 2021.

Comments

Commenting is limited to medical professionals. To comment please Log-in.

Comments on Medscape are moderated and should be professional in tone and on topic. You must declare any conflicts of interest related to your comments and responses. Please see our Commenting Guide for further information. We reserve the right to remove posts at our sole discretion.

Return to Article

Post as: