When there is no response to first-line treatment with an antidepressant, switching medications is recommended. The addition of a second antidepressant is only recommended in the first line in cases of partial response after 4-6 weeks of therapy.
In cases of partial response or nonresponse to second-line antidepressant treatment, optimizing the dose of the initial antidepressant is recommended with a high priority level. Slightly higher remission rates may be obtained with between-class medication switches vs within-class switches.
Learn more about pharmacotherapy for TRD.
Medscape © 2021 WebMD, LLC
Any views expressed above are the author's own and do not necessarily reflect the views of WebMD or Medscape.
Cite this: Ravinder N. Bhalla. Fast Five Quiz: Treatment-Resistant Depression - Medscape - Aug 19, 2021.