Fast Five Quiz: Non–Small Cell Lung Cancer (NSCLC) and RET Mutation

Maurie Markman, MD


August 22, 2022

The most common rearrangement in RET-positive cases is between intron 11 and intron 15 of the K1F5B gene. The second most common arrangement is with the CCDC6 gene. Conversely, K1F5B is the most frequently seen rearrangement in NSCLC, constituting about 70% of RET-positive cases. RET fusion is thought to be exclusive of EGFR, ALK, KRAS, and BRAF mutations, which indicates that it has its own oncogenic driver potential.

The most common gene fusion partners in RET are KIF5B and CCDC6. Less common fusion partners include NCOA4, TRIM33, ZNF477P, ERCC1, and CLIP1.

Learn more about the genetics of NSCLC.


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