According to the ACC guidelines, either an ARNI/ACEI/ARB or beta-blocker should be initiated in patients with new-onset stage C HFrEF. In many cases, an ARNI/ACEI/ARB and a beta-blocker can be started at the same time, and experts increasingly feel that this approach is most beneficial. Regardless of the initiation sequence, agents should be uptitrated to the highest tolerated dose or to target doses in a timely manner (eg, every 2 weeks).
Learn more about the treatment of HFrEF.
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Cite this: Alanna Morris. Fast Five Quiz: Heart Failure With Reduced Ejection Fraction (HFrEF) Treatment Optimization - Medscape - Sep 09, 2021.