Fast Five Quiz: Heart Failure With Reduced Ejection Fraction (HFrEF) Treatment Optimization

Alanna Morris, MD; Michael Weber, MD; Jeffrey J. Hsu, MD


November 16, 2023

A washout period when switching from an ACEI to an ARNI is required to reduce the risk for angioedema; ACEI and ARNI combination therapy is contraindicated owing to this risk. Other contraindications that have been linked to ARNI include medication allergy, hyperkalemia, hypotension, and pregnancy; combination therapy with aliskiren is not recommended.

An ARNI may also be used in combination with an SGLT2 inhibitor; however, as these medications both have diuretic effects, dosages of concomitantly prescribed diuretics may need to be adjusted.

Learn more about the role of ARNIs in the treatment of HFrEF.


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