Fast Five Quiz: Sildenafil (Viagra)

Mary L. Windle, PharmD


August 04, 2021

Sildenafil use is contraindicated in patients taking the following medications:

  • Atazanavir

  • Cobicistat

  • Elvitegravir-cobicistat-emtricitabine-tenofovir disoproxil fumarate

  • Isosorbide dinitrate

  • Isosorbide mononitrate

  • Nelfinavir

  • Nitroglycerin

  • Riociguat

  • Vericiguat

Riociguat is a guanylate cyclase stimulator used to treat pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension. Coadministration of PDE-5 inhibitors (eg, avanafil, sildenafil, tadalafil, vardenafil) and guanylate cyclase stimulators is contraindicated owing to risk for additive hypotension. They should not be administered within 24 hours of each other.

Review drug interactions with sildenafil.


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