Fast Five Quiz: Sildenafil (Viagra)

Mary L. Windle, PharmD

Disclosures

August 04, 2021

Sildenafil is recognized as having low general toxicity with no reproductive toxicity, genotoxicity, or carcinogenic properties. Single doses of as much as 800 mg have been found to result in an increased frequency and severity of adverse effects associated with lower doses. Dialysis does not help clear sildenafil because the drug is highly bound to plasma proteins and is not renally excreted. No antidotes are available for sildenafil.

Clinical studies of higher-than-recommended sildenafil doses showed dose-related increases in the frequency of visual adverse events; however, no clear relationship between dose and maximum blood pressure decreases or clinically significant changes on electrocardiography have been established. Patients who take sildenafil more often than once daily have an increased frequency of transient muscle ache without evidence of muscle damage.

Read more about other warnings and cautions for sildenafil use.

This Fast Five Quiz was excerpted and adapted from the Medscape Drugs & Diseases articles Erectile Dysfunction and sildenafil.

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